After a long illness borne with much grace and dignity, Iain MacIntyre died in London on 18 September 2008. He had led a most distinguished career over five decades as a major figure in the field of calcium-regulating hormones and bone metabolism, with his many scientific achievements marked by originality as well as biological and medical importance. Among his many accomplishments were the co-discovery with Harold Copp of the hormone calcitonin, whose glandular origin, structure and biological and medical functions he defined. Iain also was the first to isolate and sequence, with colleagues, the novel human neuropeptide calcitonin gene-related peptide, demonstrating its role as a potent vasodilator. Subsequently Iain defined the multiple phenotypic consequences attributable to nitric oxide production by different enzymes in a tissue-specific fashion. A major educational contribution was in conceiving and organizing an important biennial series of international endocrine meetings held between 1967 and 1981. These were memorable occasions, at which calcium metabolism and bone metabolism featured strongly, but so too did the latest topics in endocrinology. The meetings featured outstanding national and international speakers from many fields, and pushed the participants to think beyond the confines of their immediate interests. The published proceedings of those conferences are well worth re-reading, with much content that was prophetic and much that provides genuinely valuable history. These meetings played a very influential international role and had a seminal inspiring influence on the international careers of many young researchers who have since achieved major distinction. Iain was elected a Fellow of the Royal Society in 1996, served on a Sectional Committee, and was awarded the Buchanan Medal of the Society in 2006.
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